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Missouri's top race is an open contest for U.S. Senate following the retirement of Republican Roy Blunt.

Two top aides have left Sen. John McCain's presidential campaign, which has been struggling in the polls and with fundraising. The move could affect how the Republican field is shaping up.

Before Monday's Virginia Tech deaths, the deadliest campus shooting in the United States was at the University of Texas on Aug. 1, 1966. Firing from the top of a tower on campus, Charles Whitman killed 16 people and injured 31. An eyewitness looks back.

Should she secure the Democratic nomination, Vice President Kamala Harris would join a short list of female candidates from major parties to top a presidential ticket.

A top ally to House Minority Leader Nancy Pelosi, the California Democrat announced Monday that he will not seek re-election after serving in Congress for 40 years.

There have been 40 consecutive drawings since the last time someone won Powerball's top prize on New Year's Day. The jackpot ranks as the eighth largest in U.S. lottery history.

With Joe Biden leading in the polls, Democrats are haunted by the ghosts of 2016 when Hillary Clinton led, too. But there are a few key factors that make this year's election different.

NCAA basketball's Final Four teams will play in New Orleans Saturday, to decide who will play in Monday night's title game. The first match-up pits Louisville against No. 1 Kentucky. In the second game, Ohio State will face the University of Kansas.

Harry Houdini famously tried to escape from being buried alive — and famously failed. Recently, escape artist Antony Britton tried to do what Houdini couldn't. He describes the view from down under.

A Spanish court named Calatrava, designer of New York's Ground Zero transport hub, a suspect in alleged contract fraud. Prosecutors say he got $3.6 million for a convention center that wasn't built.